Nanomedicine, Volume IIA: Biocompatibility

© 2003 Robert A. Freitas Jr. All Rights Reserved.

Robert A. Freitas Jr., Nanomedicine, Volume IIA: Biocompatibility, Landes Bioscience, Georgetown, TX, 2003


 

References 2700-2799

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2701. A.J. Schwab, C.A. Goresky, “Hepatic uptake of protein-bound ligands: effect of an unstirred Disse space,” Am. J. Physiol. 270(May 1996):G869-G880.

2702. E.M. Kekonen, V.P. Jauhonen, I.E. Hassinen, “Oxygen and substrate dependence of hepatic cellular respiration: sinusoidal oxygen gradient and effects of ethanol in isolated perfused liver and hepatocytes,” J. Cell. Physiol. 133(October 1987):119-126.

2703. E. Wisse, R.B. De Zanger, K. Charels, P. Van Der Smissen, R.S. McCuskey, “The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse,” Hepatology 5(July-August 1985):683-692. See also: http://cyto.vub.ac.be/~cyto/

2704. L. Bouwens, M. Baekeland, R.B. De Zanger, E. Wisse, “Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver,” Hepatology 6(July-August 1986):718-722.

2705. M. Naito, E. Wisse, “Filtration effect of endothelial fenestrations on chylomicron transport in neonatal rat liver sinusoids,” Cell Tiss. Res. 190(10 July 1978):371-382.

2706. R. Fraser, L.M. Bowler, W.A. Day, B. Dobbs, H.D. Johnson, D. Lee, “High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers,” Br. J. Exp. Pathol. 61(April 1980):222-228.

2707. R. Fraser, B.R. Dobbs, G.W.T. Roger, “Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis,” Hepatology 21(March 1995):863-874. See also: Robin Fraser et al, “The Liver Sieve,” University of Otago, Christchurch School of Medicine; http://www.chmeds.ac.nz/go/dept-pathology/research/lsieve/lsieve.htm

2708. F. Braet, R. De Zanger, E. Crabbe, E. Wisse, “New observations on cytoskeleton and fenestrae in isolated rat liver sinusoidal endothelial cells,” J. Gastroenterol. Hepatol. 10(1995):S3-S7 (Suppl 1).

2709. Z. Gatmaitan, L. Varticovski, I. Ling, R. Mikkelsen, A.M. Steffan, I.M. Arias, “Studies on fenestral contraction in rat liver endothelial cells in culture,” Am. J. Pathol. 148(June 1996):2027-2041.

2710. A.M. Steffan, C.A. Pereira, A. Bingen, M. Valle, J.P. Martin, F. Koehren, C. Royer, J.L. Gendrault, A. Kirn, “Mouse hepatitis virus type 3 infection provokes a decrease in the number of sinusoidal endothelial cell fenestrae both in vivo and in vitro,” Hepatology 22(August 1995):395-401.

2711. E. Wisse, “Ultrastructure and Function of Kupffer Cells and Other Sinusoidal Cells in the Liver, “ in E. Wisse, D.L. Knook, eds., Kupffer Cells and Other Liver Sinusoidal Cells, Elsevier/North-Holland Biomedical Press, New York, 1977, pp. 33-60.

2712. A.M. Steffan, J.L. Gendrault, A. Kirn, “Increase in the number of fenestrae in mouse endothelial liver cells by altering the cytoskeleton with cytochalasin B,” Hepatology 7(November-December 1987):1230-1238.

2713. Robert G. Meeks, Steadman D. Harrison, Richard J. Bull, eds., Hepatotoxicology, CRC Press, Boca Raton, 1991.

2714. F. Braet, R. De Zanger, D. Jans, I. Spector, E. Wisse, “Microfilament-disrupting agent latrunculin A induces an increased number of fenestrae in rat liver sinusoidal endothelial cells: comparison with cytochalasin B,” Hepatology 24(September 1996):627-635.

2715. F. Braet, I. Spector, R. De Zanger, E. Wisse, “A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide,” Proc. Natl. Acad. Sci. (USA) 95(10 November 1998):13635-13640.

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2717. T. Horn, P. Christoffersen, J.H. Henriksen, “Alcoholic liver injury: defenestration in noncirrhotic livers – a scanning electron microscopic study,” Hepatology 7(January-February 1987):77-82; T. Horn, J. Junge, P. Christoffersen, “Early alcoholic liver injury: changes of the Disse space in acinar zone 3,” Liver 5(December 1985):301-310.

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2719. T. Mori, T. Okanoue, H. Kanaoka, Y. Sawa, K. Kashima, “Experimental study of the reversibility of sinusoidal capillarization,” Alcohol Alcohol. 29(1994):67-74 (Suppl 1).

2720. F. Braet, R. De Zanger, M. Baekeland, E. Crabbe, P. Van Der Smissen, E. Wisse, “Structure and dynamics of the fenestrae-associated cytoskeleton of rat liver sinusoidal endothelial cells,” Hepatology 21(January 1995):180-189.

2721. F. Braet, W.H. Calle, R.B. De Zanger, B.G. De Grooth, A.K. Raap, H.J. Tanke, E. Wisse, “Comparative atomic force and scanning electron microscopy: an investigation on fenestrated endothelial cells in vitro,” J. Microsc. 181(January 1996):10-17.

2722. T. Daemen, M. Velinova, J. Regts, M. de Jager, R. Kalicharan, J. Donga, J.J. van der Want, G.L. Scherphof, “Different intrahepatic distribution of phosphatidylglycerol and phosphatidylserine liposomes in the rat,” Hepatology 26(August 1997):416-423; but compare: E.L. Romero, M.J. Morilla, J. Regts, G.A. Koning, G.L. Scherphof, “On the mechanism of hepatic transendothelial passage of large liposomes,” FEBS Lett. 448(1 April 1999):193-196.

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2724. E.I. Vidins, R.S. Britton, A. Medline, L.M. Blendis, Y. Israel, H. Orrego, “Sinusoidal caliber in alcoholic and nonalcoholic liver disease: diagnostic and pathogenic implications,” Hepatology 5(May-June 1985):408-414.

2725. J.X. Zhang, W. Pegoli Jr., M.G. Clemens, “Endothelin-1 induces direct constriction of hepatic sinusoids,” Am. J. Physiol. 266(April 1994):G624-G632; J.X. Zhang, M. Bauer, M.G. Clemens, “Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver,” Am. J. Physiol. 269(August 1995):G269-G277; B.H. Pannen, M. Bauer, J.X. Zhang, J.L. Robotham, M.G. Clemens, “Endotoxin pretreatment enhances portal venous contractile response to endothelin-1,” Am. J. Physiol. 270(January 1996):H7-H15.

2726. Y. Ito, M. Katori, M. Majima, A. Kakita, “Constriction of mouse hepatic venules and sinusoids by endothelins through ETB receptor subtype,” Int. J. Microcirc. Clin. Exp. 16(September-October 1996):250-258.

2727. H. Wadenvik, J. Kutti, “The effect of an isoprenalin infusion on the splenic blood flow and intrasplenic platelet kinetics,” Eur. J. Haematol. 39(July 1987):7-13; “The effect of an adrenalin infusion on the splenic blood flow and intrasplenic platelet kinetics,” Br. J. Haematol. 67(October 1987):187-192.

2728. H. Ashida, K. Takagi, A. Nishioka, Y. Kotorura, J. Utsunomiya, “Hemodynamic changes in splenic blood flow during and after distal splenorenal shunt,” Am. J. Gastroenterol. 85(December 1990):1609-1613.

2729. K. Haag, A. Weimann, O. Zeller, C. Spamer, M. Sellinger, M. Rossle, “Splenic size and duplex sonography determination of blood flow in the vena lienalis and vena portae in liver cirrhosis,” Bildgebung 59(June 1992):80-83. In German.

2730. A. Oguro, H. Taniguchi, H. Koyama, H. Tanaka, K. Miyata, K. Takeuchi, T. Inaba, H. Nakahashi, T. Takahashi, “Quantification of human splenic blood flow (quantitative measurement of splenic blood flow with H2(15)O and a dynamic state method:1,” Ann. Nucl. Med. 7(November 1993):245-250; “Relationship between liver function and splenic blood flow(quantitative measurement of splenic blood flow with H2(15)O and a dynamic state method: 2,” Ann. Nucl. Med. 7(November 1993):251-255.

2731. M.J. Blomley, M. Kormano, R. Coulden, J. Lim-Dunham, P. Dawson, M.J. Lipton, “Splenic blood flow: evaluation with computed tomography,” Acad. Radiol. 4(January 1997):13-20.

2732. L.P. Smith, K.W. Hunter, E.C. Oldfield, G.T. Strickland, “Murine malaria: blood clearance and organ sequestration of Plasmodium yoelii-infected erythrocytes,” Infect. Immun. 38(October 1982):162-167.

2733. T. Nakamura, S. Hasegawa, H. Shio, N. Uyesaka, “Rheologic and pathophysiologic significance of red cell passage through narrow pores,” Blood Cells 20(1994):151-165, 166-168 (discussion).

2734. J. Horton, M.E. Ogden, S. WIlliams, D. Coln, “The importance of splenic blood flow in clearing pneumococcal organisms,” Ann. Surg. 195(February 1982):172-176.

2735. S.M. Moghimi, C.J.H. Porter, I.S. Muir, L. Illum, S.S. Davis, “Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating,” Biochem. Biophys. Res. Commun. 177(14 June 1991):861-866.

2736. E. Claassen, N. Van Rooijen, “The effect of elimination of macrophages on the tissue distribution of liposomes containing [3H]methotrexate,” Biochim. Biophys. Acta 802(20 December 1984):428-434.

2737. Tsuneo Fujita, “A scanning electron microscope study of the human spleen,” Arch. Histol. Jpn. 37(November 1974):187-216.

2738. J.H. van Krieken, J. te Velde, “Normal histology of the human spleen,” Am. J. Surg. Pathol. 12(October 1988):777-785.

2739. Thomas Caceci, “Lymphatic System: Spleen and Other Organs,” VM8054 Veterinary Histology, Exercise 13; http://education.vetmed.vt.edu/Curriculum/VM8054/Labs/Lab13/Lab13.htm

2740. Birte Steiniger, Peter Barth, Microanatomy and Function of the Spleen, Springer-Verlag, New York, 1999.

2741. Amy Chadburn, “The spleen: anatomy and anatomical function,” Semin. Hematol. 37(January 2000):13-21 (Suppl 1).

2742. T. Satoh, R. Takeda, H. Oikawa, R. Satodate, “Immunohistochemical and structural characteristics of the reticular framework of the white pulp and marginal zone in the human spleen,” Anat. Rec. 249(December 1997):486-494.

2743. G. Kraal, “Cells in the marginal zone of the spleen,” Int. Rev. Cytol. 132(1992):31-74.

2744. T. Snook, “The origin of the follicular capillaries in the human spleen,” Am. J. Anat. 144(September 1975):113-117.

2745. E.E. Schmidt, I.C. MacDonald, A.C. Groom, “Microcirculatory pathways in normal human spleen, demonstrated by scanning electron microscopy of corrosion casts,” Am. J. Anat. 181(March 1988):253-266; “Comparative aspects of splenic microcirculatory pathways in mammals: the region bordering the white pulp,” Scanning Microsc. 7(June 1993):613-628.

2746. G. Adebahr, “Fat embolism in the spleen,” Z. Rechtsmed. 94(1985):309-315. In German.

2747. K. Yamamoto, N. Arimasa, T. Yamamoto, K. Tokuyama, T. Kobayashi, T. Itoshima, “Scanning electron microscopy of the perimarginal cavernous sinus plexus of the human spleen,” Scan. Electron. Microsc. 3(1979):763-768.

2748. M.I. Barnhart, C.A. Baechler, J.M. Lusher, “Arteriovenous shunts in the human spleen,” Am. J. Hematol. 1(1976):105-114.

2749. S. Irino, T. Murakami, T. Fujita, “Open circulation in the human spleen: Dissection scanning electron microscopy of conductive-stained tissue and observation of resin vascular casts,” Arch. Histol. Jpn. 40(September 1977):297-304.

2750. M. Brozman, J. Jakubovsky, “The red pulp of the human spleen. Structural basis of blood filtration,” Z. Mikrosk. Anat. Forsch. 103(1989):316-328.

2751. D.A. McCarthy, J.R. Archer, P.A. Biro, “Lecture 10: Immunophysiology 2: The structure and function of secondary lymphoid organs,” Basic Immunology, Queen Mary University of London, 2 October 2000; http://alpha.qmul.ac.uk/~ugbt110/basicimmunology/lecweek4.doc

2752. G.R. Cokelet, “Dynamics of erythrocyte motion in filtration tests and in vivo flow,” Scand. J. Clin. Lab. Invest. Suppl. 156(1981):77-82.

2753. E. Ogura, P.J. Abatti, T. Moriizumi, “Measurement of human red blood cell deformability using a single micropore on a thin Si3N4 film,” IEEE Trans. Biomed. Eng. 38(August 1991):721-726.

2754. E. Ogura, P.J. Abatti, T. Moriizumi, “Passage time measurement of individual red blood cells through arrays micropores on Si3N4 membrane,” J. Biomed. Eng. 13(November 1991):503-506.

2755. R. Skalak, P.I. Branemark, R. Ekholm, “Erythrocyte adherence and diapedesis. Some aspects of a possible mechanism based on vital and electron microscopic observations,” Angiology 21(April 1970):224-239.

2756. I.C. MacDonald, D.M. Ragan, E.E. Schmidt, A.C. Groom, “Kinetics of red blood cell passage through interendothelial slits into venous sinuses in rat spleen, analyzed by in vivo microscopy,” Microvasc. Res. 33(January 1987):118-134.

2757. I.C. MacDonald, E.E. Schmidt, A.C. Groom, “The high splenic hematocrit: a rheological consequence of red cell flow through the reticular meshwork,” Microvasc. Res. 42(July 1991):60-76.

2758. V. Lorian, O. Zak, J. Suter, C. Bruecher, “Staphylococci, in vitro and in vivo,” Diagn. Microbiol. Infect. Dis. 3(September 1985):433-444.

2759. R. Satodate, A. Suzuki, T. Iwasaki, S. Sasou, “Distribution of blood-borne particles of two different sizes in rat spleens,” Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 51(1986):97-105.

2760. D.M. Ragan, E.E. Schmidt, I.C. MacDonald. A.C. Groom, “Spontaneous cyclic contractions of the capillary wall in vivo, impeding red cell flow: a quantitative analysis. Evidence for endothelial contractility,” Microvasc. Res. 36(July 1988):13-30.

2761. A.H. Rebar, H.B. Lewis, D.B. DeNicola, W.H. Halliwell, G.D. Boon, “Red cell fragmentation in the dog: an editorial review,” Vet. Pathol. 18(July 1981):415-426.

2762. Robert A. Freitas Jr., “Microbivores: Artificial Mechanical Phagocytes using Digest and Discharge Protocol,” Zyvex preprint, March 2001; http://www.zyvex.com/Publications/articles/Microbivores.html. See also: “Microbivores: Artificial Mechanical Phagocytes,” Foresight Update No. 44, 31 March 2001, pp. 11-13; http://www.imm.org/Reports/Rep025.html and http://www.kurzweilai.net/meme/frame.html?main=/articles/art0453.html

2763. R. Shah, G.H. Mahour, E.G. Ford, P. Stanley, “Partial splenic embolization. An effective alternative to splenectomy for hypersplenism,” Am. Surg. 56(December 1990):774-777.

2764. L. Illum, S.S. Davis, “The Targeting of Drugs Parenterally by Use of Microspheres,” J. Parenter. Sci. Tech. 36(November-December 1982):242-248.

2765. P.J. Lea, M. Silverman, R. Hegele, M.J. Hollenberg, “Tridimensional ultrastructure of glomerular capillary endothelium revealed by high-resolution scanning electron microscopy,” Microvasc. Res. 38(November 1989):296-308.

2766. P.J. MacPhee, “Fluid uptake by the renal medullary vasa recta: an estimate based on a quantitative analysis of the distribution of fenestrae in the vasa recta of young Sprague-Dawley rats,” Exp. Physiol. 83(January 1998):23-34.

2767. A. Bohle, H. von Gise, B. Schubert, M. Wehrmann, E. Mikeler, G. Neuhaus, U. Spath, “Transmission and scanning electron microscopy investigations on the structure of the ultrafilter of glomeruli in human acute renal failure,” Am. J. Nephrol. 8(1988):112-117.

2768. A.P. Evan, F.C. Luft, V. Gattone, B.A. Connors, D.A. Macarron, L.R. Willis, “The glomerular filtration barrier in the spontaneously hypertensive rat,” Hypertension 3(May-June 1981):I154-I161.

2769. F.C. Luft, A.P. Evan, “Glomerular filtration barrier in aminoglycoside-induced nephrotoxic acute renal failure,” Ren. Physiol. 3(1980):265-271; F.C. Luft, G.R. Aronoff, A.P. Evan, B.A. Connors, “The effect of aminoglycosides on glomerular endothelium: a comparative study,” Res. Commun. Chem. Pathol. Pharmacol. 34(October 1981):89-95.

2770. C. Cojocel, N. Docius, K. Maita, S.D. Sleight, J.B. Hook, “Effects of aminoglycosides on glomerular permeability, tubular reabsorption, and intracellular catabolism of the cationic low-molecular-weight protein lysozyme,” Toxicol. Appl. Pharmacol. 68(30 March 1983):96-109; C. Cojocel, N. Docius, E. Ceacmacudis, K. Baumann, “Nephrotoxic effects of aminoglycoside treatment on renal protein reabsorption and accumulation,” Nephron 37(1984):113-119; C. Cojocel, N. Docius, K. Maita, J.H. Smith, J.B. Hook, “Renal ultrastructural and biochemical injuries induced by aminoglycosides,” Environ. Health Perspect. 57(August 1984):293-299.

2771. A.P. Evan, V.H. Gattone 2nd, R.S. Filo, S.B. Leapman, E.J. Smith, F.C. Luft, “Glomerular endothelial injury related to renal perfusion. A scanning electron microscope study,” Transplantation 35(May 1983):436-441.

2772. E.S. Ofjord, G. Clausen, “Relative flow of blood cells, platelets, and microspheres in outer and inner renal cortex,” Am. J. Physiol. 251(August 1986):H242-H246.

2773. J.L. McNay, Y. Abe, “Pressure dependent heterogeneity of renal cortical blood flow in dogs,” Circ. Res. 27(1970):571-587.

2774. L. Morkrid, J. Ofstad, Y. Willassen, “Effect of steric restriction on the intracortical distribution of microspheres in the dog kidney,” Circ. Res. 39(October 1976):608-615.

2775. J.R. Utley, W.G. Marshall, G.B. Boatman, G. Dickerson, G.B. Ernst, M.E. Daughtery, “Trapping, nontrapping, and release of nine and fifteen micron spheres in dog kidneys,” Surgery 87(February 1980):222-229.

2776. S. Gelman, K. Patel, S.P. Bishop, K.L. Fowler, L.R. Smith, “Renal and splanchnic circulation during infrarenal aortic cross-clamping,” Arch. Surg. 119(December 1984):1394-1399.

2777. A.M. Stone, T. Stein, J. LaFortune, L. Wise, “Changes in intrarenal blood flow during sepsis,” Surg. Gynecol. Obstet. 148(May 1979):731-734.

2778. L. Morkrid, J. Ofstad, Y. Willassen, “Diameter of afferent arterioles during autoregulation estimated from microsphere data in the dog kidney,” Circ. Res. 42(February 1978):181-191.

2779. N.S. Nahman et al, “Microsphere-adenoviral complexes target and transduce the glomerulus in vivo,” Kidney Int. 58(October 2000):1500-1510.

2780. Aurelie Adwards, Erik P. Silldforff, Thomas L. Pallone, “The Renal Medullary Microcirculation,” Frontiers in Bioscience 5(1 June 2000):e36-e52; http://www.bioscience.org/2000/v5/e/edwards/fulltext.htm

2781. J. Ofstad, L. Morkrid, Y. Willassen, “Diameter of the afferent arteriole in the dog kidney estimated by the microsphere method,” Scand. J. Clin. Lab. Invest. 35(December 1975):767-774.

2782. J.E. Dion, R.N. Rankin, F. Vinuela, A.J. Fox, A.C. Wallace, M. Mervart, “Dextran microsphere embolization: experimental and clinical experience with radiologic-pathologic correlation. Work in progress,” Radiology 160(September 1986):717-721.

2783. A. Mimran, D. Casellas, “Microsphere size and determination of intrarenal blood flow distribution in the rat,” Pflugers Arch. 382(November 1979):233-240.

2784. G.A. Tanner, “Effects of kidney tubule obstruction on glomerular function in rats,” Am. J. Physiol. 237(November 1979):F379-F385.

2785. G.A. Tanner, L.C. Knopp, “Glomerular blood flow after single nephron obstruction in the rat kidney,” Am. J. Physiol. 250(January 1986):F77-F85.

2786. W.E. Yarger, M.A. Boyd, N.W. Schrader, “Evaluation of methods of measuring glomerular and nutrient blood flow in rat kidneys,” Am. J. Physiol. 235(November 1978):H592-H600.

2787. M. Sossenheimer, J.T. Fleming, M. Steinhausen, “Passage of microspheres through vessels of normal and split hydronephrotic rat kidneys,” Am. J. Anat. 180(October 1987):185-194.

2788. D.J. Warren, J.G. Ledingham, “Measurement of intrarenal blood-flow distribution in the rabbit using radioactive microspheres,” Clin. Sci. Mol. Med. 48(January 1975):51-60.

2789. P. Gomori, “Arterio-venous shunts of the kidney,” Acta Med. Acad. Sci. Hung. 25(1968):267-272.

2790. L. Nilsson, G. Bergman, K. Falt, B. Husberg, “Development of arteriovenous shunts in rejecting rat kidneys,” Eur. Surg. Res. 17(1985):173-178; L. Nilsson, H. Ekberg, K. Falt, H. Lofberg, G. Sterner, “Renal arteriovenous shunting in rejecting allograft, hydronephrosis, or haemorrhagic hypotension in the rat,” Nephrol. Dial. Transplant. 9(1994):1634-1639; L. Nilsson, G. Sterner, H. Ekberg, “Presence of arteriovenous shunting in transplanted but not in native single kidney in the rat,” Scand. J. Urol. Nephrol. 33(December 1999):363-367.

2791. R. Zimmerman, S. Sprayregen, “Arterio-venous shunting in renal transplant rejection,” Angiology 29(January 1978):40-47.

2792. J.H. Grau, P. Gonick, A. Wilson, “Post-biopsy intrarenal arteriovenous fistula,” J. Urol. 122(August 1979):233-236.

2793. D.G. Matsell, D.P. Jones, T.F. Boulden, E.M. Burton, S.L. Baum, I.L. Tonkin, “Arteriovenous fistula after biopsy of renal transplant kidney: diagnosis and treatment,” Pediatr. Nephrol. 6(November 1992):562-564.

2794. J. Gothlin, “Arteriovenous shunting in carcinomas evaluated by a dye dilution technique,” Scand. J. Urol. Nephrol. 1(1977):159-163.

2795. K.H. Barth, R.I. White Jr., F.F. Marshall, “Quantification of arteriovenous shunting in renal cell carcinoma,” J. Urol. 125(February 1981):161-163.

2796. A. Rangel, H. Albarran, F. Gomez-Orta, M. Soriano, E. Badui, “A case of giant arteriovenous shunt in a renal carcinoma,” Rev. Invest. Clin. 49(July-August 1997):277-280.

2797. A. Battler et al, “Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infracted swine myocardium,” J. Am. Coll. Cardiol. 22(December 1993)2001-2006.

2798. R.P. Hof, A. Hof, R. Salzmann, F. Wyler, “Trapping and intramyocardial distribution of microspheres with different diameters in cat and rabbit hearts in vitro,” Basic Res. Cardiol. 76(November-December 1981):630-638.

2799. B.J. Bellhouse, F.H. Bellhouse, “Fluid mechanics of a model mitral valve and left ventricle,” Cardiovasc. Res. 6(1972):199-210.

 


Last updated on 16 April 2004